tag:blogger.com,1999:blog-6234783319349274920.post3779168404498576490..comments2024-03-28T18:03:15.049-04:00Comments on FOLIO OLIO: THURSDAY #2644Ralph Henryhttp://www.blogger.com/profile/05079364726250352589noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-6234783319349274920.post-20009564372335725092016-03-18T08:53:40.618-04:002016-03-18T08:53:40.618-04:00Thank you very much for that information. See you ...Thank you very much for that information. See you soon.Ralph Henryhttps://www.blogger.com/profile/05079364726250352589noreply@blogger.comtag:blogger.com,1999:blog-6234783319349274920.post-35834200445432607022016-03-17T21:02:16.920-04:002016-03-17T21:02:16.920-04:00Marijuana replacing drugs...yes it is true that it...Marijuana replacing drugs...yes it is true that it can have a therapeutic effect similar to many of the drugs listed...anti-anxiety (Xanax), analgesic (Vicodin), hypnotic (Ambien), antidepressant (Zoloft). I would argue against ADHD (Adderall). It has also been shown to have anti-seizure and antispasmodic effects. Clinical trial data is not conclusive for these.<br /><br />However, the main problem is "dosing". How would you dose it for antidepressant use but keep from getting tired? Same thing with anxiety. given the variability in potency from one batch to the next as well as from one "strain" to another, dosing would be a major issue. Another problem is safety. While we have a lot of anecdotal evidence that marijuana is relatively safe, it is not know what the long term effects are when used therapeutically as a drug...again..clinical trials need to do some catching up.<br /><br />Interestingly, the central nervous system as well as immune cells and other tissues are rather abundant in cannabinoid receptors...CB1, CB2, etc. Synthetic drugs that affect these receptors have been under investigation for quite some time, ones that activate the receptor as well as ones which inactivate (antagonize) the receptor. I believe there was an antagonist in development for obesity (makes sense right?...smoking pot causes the munchies...block the body's ability to activate the receptors may decrease hunger).<br /><br />In summary, its a area of research that is under intense investigation. While there is some benefit to smoking it, the dosing is a major problem for most disease states. some extracts of marijuana, such as cannabidiol, are being produced in known concentrations for reliable dosing. this may be the direction things are heading.<br /> <br />Anonymousnoreply@blogger.com